At first, Gameguard is easily removed but when I tried to hex Ragexe to open multiple clients with just the patch update however, the (2nd) string 85 C0 0F 85 CC 01 00 00 00 0F was in the way and prevented me to do so.
Thus, I resorted to what I did the last time (in October 2010).
There is a Sakexe in my Gravity > Ragnarok Online folder (and I suppose it's also in yours) and it's already unpacked.
What I did was delete Ragexe; made a copy of the Sakexe on another part of my PC (on a folder where I keep back-ups of origs) and renamed it to Ragexe and put it back in Gravity > Ragnarok Online folder.
I only play in New Chaos but I didn't delete the orig Sakexe in the Gravity > Ragnarok folder as it may be detrimental to running the game (since I could have just simply renamed it).
Having done that, I followed my own guide /heh and came up with the hex strings.
Remove GameGuard~
Search: E8 E4 19 E3 FF
Replace: 90 90 90 90 90
Open Multiple Clients~
Search: 85 C0 74 07 C6 05 A8 9A 86 00 01
Replace: 85 C0 EB 07 C6 05 A8 9A 86 00 01
Search: 85 C0 74 0E 5F 5E B8 01 00 00 00
Replace: 85 C0 EB 0E 5F 5E B8 01 00 00 00
Search: 85 C0 74 09 5F 5E 32 C0 5B 8B E5
Replace: 85 C0 EB 09 5F 5E 32 C0 5B 8B E5
Don't forget to ALWAYS make a back-up of the origs as you need them during WoE time.
